CATH Domain 2fvcA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.270	Reverse transcriptase/Diguanylate cyclase domain

Domain Context

CATH Clusters

Superfamily	3.30.70.270
Functional Family	Genome polyprotein

Enzyme Information

UniProtKB Entries (1)

Q99AU2_9HEPC

Hepatitis C virus subtype 1b

Genome polyprotein

PDB Structure

PDB	2FVC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. Tedesco, R., Shaw, A.N., Bambal, R., Chai, D., Concha, N.O., Darcy, M.G., Dhanak, D., Fitch, D.M., Gates, A., Gerhardt, W.G., Halegoua, D.L., Han, C., Hofmann, G.A., Johnston, V.K., Kaura, A.C., Liu, N., Keenan, R.M., Lin-Goerke, J., Sarisky, R.T., Wiggall, K.J., Zimmerman, M.N., Duffy, K.J. J.Med.Chem.