CATH Classification

Domain Context

CATH Clusters

Superfamily Foki Restriction Endonuclease, Chain A, domain 1
Functional Family

Enzyme Information

3.1.21.4
Type II site-specific deoxyribonuclease.
based on mapping to UniProt P14870
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.
-!- Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P14870
T2F1_PLAOK
Planomicrobium okeanokoites
Type-2 restriction enzyme FokI

PDB Structure

PDB 2FOK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure of FokI has implications for DNA cleavage.
Wah, D.A., Bitinaite, J., Schildkraut, I., Aggarwal, A.K.
Proc.Natl.Acad.Sci.Usa