CATH Classification

CATH Clusters

Superfamily 2.120.10.10
Functional Family Sialidase

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt O44049
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

O44049
O44049_TRYRA
Trypanosoma rangeli
Sialidase

PDB Structure

PDB 2FHR
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural and Kinetic Analysis of Two Covalent Sialosyl-Enzyme Intermediates on Trypanosoma rangeli Sialidase.
Watts, A.G., Oppezzo, P., Withers, S.G., Alzari, P.M., Buschiazzo, A.
J.Biol.Chem.