CATH Classification

Domain Context

CATH Clusters

Superfamily 2.80.10.50
Functional Family Polypeptide N-acetylgalactosaminyltransferase

Enzyme Information

2.4.1.41
Polypeptide N-acetylgalactosaminyltransferase.
based on mapping to UniProt Q10471
(1) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-serine. (2) UDP-N-acetyl-alpha-D-galactosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-alpha-D-galactosaminyl)-L-threonine.
-!- The glycosyl residue is transferred to threonine or serine hydroxy groups on the polypeptide core of submaxillary mucin, kappa-casein, apofetuin and some other acceptors of high molecular mass.

UniProtKB Entries (1)

Q10471
GALT2_HUMAN
Homo sapiens
Polypeptide N-acetylgalactosaminyltransferase 2

PDB Structure

PDB 2FFV
External Links
Method X-RAY DIFFRACTION
Organism Pichia
Primary Citation
Dynamic Association between the Catalytic and Lectin Domains of Human UDP-GalNAc:Polypeptide {alpha}-N-Acetylgalactosaminyltransferase-2
Fritz, T.A., Raman, J., Tabak, L.A.
J.Biol.Chem.