CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family Werner syndrome ATP-dependent helicase homolog

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q14191
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
3.1.-.-
Acting on ester bonds.
based on mapping to UniProt Q14191

UniProtKB Entries (1)

Q14191
WRN_HUMAN
Homo sapiens
Werner syndrome ATP-dependent helicase

PDB Structure

PDB 2FBT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
Perry, J.J., Yannone, S.M., Holden, L.G., Hitomi, C., Asaithamby, A., Han, S., Cooper, P.K., Chen, D.J., Tainer, J.A.
Nat.Struct.Mol.Biol.