CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Tryptase beta-2

Enzyme Information

3.4.21.59
Tryptase.
based on mapping to UniProt Q15661
Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.
-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

Q15661
TRYB1_HUMAN
Homo sapiens
Tryptase alpha/beta-1

PDB Structure

PDB 2F9P
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
X-ray Structures of Free and Leupeptin-complexed Human alpha I-Tryptase Mutants: Indication for an alpha to beta-Tryptase Transition
Rohr, K.B., Selwood, T., Marquardt, U., Huber, R., Schechter, N.M., Bode, W., Than, M.E.
J.Mol.Biol.