CATH Classification

Domain Context

CATH Clusters

Superfamily Protein tyrosine phosphatase superfamily
Functional Family Tyrosine-protein phosphatase non-receptor type 1

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P18031
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P18031
PTN1_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 1

PDB Structure

PDB 2F6V
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
1,2,3,4-Tetrahydroisoquinolinyl sulfamic acids as phosphatase PTP1B inhibitors
Klopfenstein, S.R., Evdokimov, A.G., Colson, A.-O., Fairweather, N.T., Neuman, J.J., Maier, M.B., Gray, J.L., Gerwe, G.S., Stake, G.E., Howard, B.W., Farmer, J.A., Pokross, M.E., Downs, T.R., Kasibhatla, B., Peters, K.G.
Bioorg.Med.Chem.Lett.