CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family Neuraminidase 3

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt Q9Y3R4
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

Q9Y3R4
NEUR2_HUMAN
Homo sapiens
Sialidase-2

PDB Structure

PDB 2F26
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of the Human Sialidase Neu2 E111Q-Q112E Double Mutant
Chavas, L.M.G., Kato, R., Fusi, P., Tringali, C., Venerando, B., Tettamanti, G., Monti, E., Wakatsuki, S.
To be Published