CATH Classification

Domain Context

CATH Clusters

Superfamily Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Functional Family Ubiquitin carboxyl-terminal hydrolase 7

Enzyme Information
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q93009
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Homo sapiens
Ubiquitin carboxyl-terminal hydrolase 7

PDB Structure

External Links
Organism Escherichia
Primary Citation
Structural Basis of Competitive Recognition of p53 and MDM2 by HAUSP/USP7: Implications for the Regulation of the p53-MDM2 Pathway.
Hu, M., Gu, L., Li, M., Jeffrey, P.D., Gu, W., Shi, Y.
Plos Biol.