CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease H-like superfamily/Ribonuclease H
Functional Family DNA polymerase

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt P03680
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
3.1.11.-
Exodeoxyribonucleases producing 5'-phosphomonoesters.
based on mapping to UniProt P03680

UniProtKB Entries (1)

P03681
TERM_BPPH2
Bacillus virus phi29
Primer terminal protein

PDB Structure

PDB 2EX3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition
Kamtekar, S., Berman, A.J., Wang, J., Lazaro, J.M., de Vega, M., Blanco, L., Salas, M., Steitz, T.A.
Embo J.