CATH Classification

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family Beta-secretase 1

Enzyme Information

3.4.23.45
Memapsin 1.
based on mapping to UniProt Q9Y5Z0
Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
-!- Can cleave beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

Q9Y5Z0
BACE2_HUMAN
Homo sapiens
Beta-secretase 2

PDB Structure

PDB 2EWY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human BACE2 in complex with a hydroxyethylamine transition state inhibitor
Ostermann, N., Eder, J., Eidhoff, U., Zink, F., Hassiepen, U., Worpenberg, S., Maibaum, J., Simic, O., Hommel, U., Gerhartz, B.
J.Mol.Biol.