CATH Classification

Domain Context

CATH Clusters

Superfamily Bira Bifunctional Protein; Domain 2
Functional Family Bifunctional ligase/repressor BirA

Enzyme Information

6.3.4.15
Biotin--[biotin carboxyl-carrier protein] ligase.
based on mapping to UniProt P06709
ATP + biotin + [biotin carboxyl-carrier protein]-L-lysine = AMP + diphosphate + [biotin carboxyl-carrier protein]-N(6)-biotinyl-L-lysine.
-!- The enzyme biotinylates a biotin carboxyl-carrier protein that is part of an acetyl-CoA carboxylase complex, enabling its subsequent carboxylation by EC 6.3.4.14. -!- The carboxyl group is eventually transferred to acetyl-CoA by EC 2.1.3.15. -!- In some organisms the carrier protein is part of EC 6.4.1.2.

UniProtKB Entries (1)

P06709
BIRA_ECOLI
Escherichia coli K-12
Bifunctional ligase/repressor BirA

PDB Structure

PDB 2EWN
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Co-repressor Induced Order and Biotin Repressor Dimerization: A Case for Divergent Followed by Convergent Evolution.
Wood, Z.A., Weaver, L.H., Brown, P.H., Beckett, D., Matthews, B.W.
J.Mol.Biol.