CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Rho-associated protein kinase 1

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt Q13464
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13464
ROCK1_HUMAN
Homo sapiens
Rho-associated protein kinase 1

PDB Structure

PDB 2ESM
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
The Structure of Dimeric ROCK I Reveals the Mechanism for Ligand Selectivity.
Jacobs, M., Hayakawa, K., Swenson, L., Bellon, S., Fleming, M., Taslimi, P., Doran, J.
J.Biol.Chem.