CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.8 | Helicase, Ruva Protein; domain 3 |
|
1.10.8.100 | Ribosomal RNA adenine dimethylase-like, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Ribosomal RNA adenine dimethylase-like, domain 2 |
| Functional Family |
Enzyme Information
| 2.1.1.184 |
23S rRNA (adenine(2085)-N(6))-dimethyltransferase.
based on mapping to UniProt P13956
2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L- homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA.
-!- ErmC is a methyltransferase that confers resistance to the macrolide- lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at adenine(2085). -!- Formerly EC 2.1.1.48.
|
UniProtKB Entries (1)
| P13956 |
ERM_BACIU
Bacillus subtilis
RRNA adenine N-6-methyltransferase
|
PDB Structure
| PDB | 2ERC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria.
Biochemistry
|