CATH Classification

Domain Context

CATH Clusters

Superfamily Vaccinia Virus protein VP39
Functional Family

Enzyme Information

2.1.1.184
23S rRNA (adenine(2085)-N(6))-dimethyltransferase.
based on mapping to UniProt P13956
2 S-adenosyl-L-methionine + adenine(2085) in 23S rRNA = 2 S-adenosyl-L- homocysteine + N(6)-dimethyladenine(2085) in 23S rRNA.
-!- ErmC is a methyltransferase that confers resistance to the macrolide- lincosamide-streptogramin B group of antibiotics by catalyzing the methylation of 23S rRNA at adenine(2085). -!- Formerly EC 2.1.1.48.

UniProtKB Entries (1)

P13956
ERM_BACIU
Bacillus subtilis
RRNA adenine N-6-methyltransferase

PDB Structure

PDB 2ERC
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria.
Bussiere, D.E., Muchmore, S.W., Dealwis, C.G., Schluckebier, G., Nienaber, V.L., Edalji, R.P., Walter, K.A., Ladror, U.S., Holzman, T.F., Abad-Zapatero, C.
Biochemistry