CATH Domain 2eg5E01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1200	Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A
	1.10.1200.270	Methyltransferase, alpha-helical capping domain

Domain Context

CATH Clusters

Superfamily	Methyltransferase, alpha-helical capping domain
Functional Family

Enzyme Information

2.1.1.158

7-methylxanthosine synthase.

based on mapping to UniProt A4GE69

S-adenosyl-L-methionine + xanthosine = S-adenosyl-L-homocysteine + 7-methylxanthosine.

-!- The enzyme is specific for xanthosine, as XMP and xanthine cannot act as substrates. -!- The enzyme does not have N(1)- or N(3)- methylation activity. -!- This is the first methylation step in the production of caffeine.

UniProtKB Entries (1)

A4GE69

XMT1_COFCA

Coffea canephora

7-methylxanthosine synthase 1

PDB Structure

PDB	2EG5
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	The structure of two N-methyltransferases from the caffeine biosynthetic pathway McCarthy, A.A., McCarthy, J.G. Plant Physiol.