CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
| Superfamily | Vaccinia Virus protein VP39 |
| Functional Family | Salicylate/benzoate carboxyl methyltransferase |
Enzyme Information
| 2.1.1.160 |
Caffeine synthase.
based on mapping to UniProt A4GE70
(1) S-adenosyl-L-methionine + 3,7-dimethylxanthine = S-adenosyl-L- homocysteine + 1,3,7-trimethylxanthine. (2) S-adenosyl-L-methionine + 1,7-dimethylxanthine = S-adenosyl-L- homocysteine + 1,3,7-trimethylxanthine. (3) S-adenosyl-L-methionine + 7-methylxanthine = S-adenosyl-L- homocysteine + 3,7-dimethylxanthine.
-!- Paraxanthine is the best substrate for this enzyme but the paraxanthine pathway is considered to be a minor pathway for caffeine biosynthesis.
|
UniProtKB Entries (1)
| A4GE70 |
DXMT1_COFCA
Coffea canephora
3,7-dimethylxanthine N-methyltransferase
|
PDB Structure
| PDB | 2EFJ |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The structure of two N-methyltransferases from the caffeine biosynthetic pathway
Plant Physiol.
|