CATH Classification

Domain Context

CATH Clusters

Superfamily ADC-like domains
Functional Family Acetylene hydratase

Enzyme Information

4.2.1.112
Acetylene hydratase.
based on mapping to UniProt Q71EW5
Acetaldehyde = acetylene + H(2)O.
-!- The tungsten center binds a water molecule that is activated by an adjacent aspartate residue, enabling it to attack acetylene bound in a distinct hydrophobic pocket. -!- Ethylene cannot act as a substrate.

UniProtKB Entries (1)

Q71EW5
AHY_PELAE
Pelobacter acetylenicus
Acetylene hydratase

PDB Structure

PDB 2E7Z
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase
Seiffert, G.B., Ullmann, G.M., Messerschmidt, A., Schink, B., Kroneck, P.M.H., Einsle, O.
Proc.Natl.Acad.Sci.Usa