CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.1130 | btk motif of tyrosine-protein kinase itk |
|
4.10.1130.10 | btk motif of tyrosine-protein kinase itk |
Domain Context
CATH Clusters
| Superfamily | btk motif of tyrosine-protein kinase itk |
| Functional Family |
Enzyme Information
| 2.7.10.2 |
Non-specific protein-tyrosine kinase.
based on mapping to UniProt Q08881
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.
|
UniProtKB Entries (1)
| Q08881 |
ITK_HUMAN
Homo sapiens
Tyrosine-protein kinase ITK/TSK
|
PDB Structure
| PDB | 2E6I |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structure of the BTK motif of tyrosine-protein kinase ITK from human
To be Published
|