CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.59.20
Functional Family

Enzyme Information

6.3.4.19
tRNA(Ile)-lysidine synthetase.
based on mapping to UniProt O67728
(tRNA(Ile2))-cytidine(34) + L-lysine + ATP = (tRNA(Ile2))-lysidine(34) + AMP + diphosphate + H(2)O.
-!- The bacterial enzyme modifies the wobble base of the CAU anticodon of tRNA(Ile) at the oxo group in position 2 of cytidine(34). -!- This modification determines both codon and amino acid specificities of tRNA(Ile).

UniProtKB Entries (1)

O67728
TILS_AQUAE
Aquifex aeolicus VF5
TRNA(Ile)-lysidine synthase

PDB Structure

PDB 2E21
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis of the initial binding of tRNA(Ile) lysidine synthetase TilS with ATP and L-lysine
Kuratani, M., Yoshikawa, Y., Bessho, Y., Higashijima, K., Ishii, T., Shibata, R., Takahashi, S., Yutani, K., Yokoyama, S.
To be Published