CATH Classification

Domain Context

CATH Clusters

Superfamily HRDC domain
Functional Family Werner syndrome ATP-dependent helicase homolog

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q14191
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
3.1.-.-
Acting on ester bonds.
based on mapping to UniProt Q14191

UniProtKB Entries (1)

Q14191
WRN_HUMAN
Homo sapiens
Werner syndrome ATP-dependent helicase

PDB Structure

PDB 2E1F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the HRDC domain of human Werner syndrome protein, WRN
Kitano, K., Yoshihara, N., Hakoshima, T.
J.Biol.Chem.