CATH Classification

Domain Context

CATH Clusters

Superfamily Cupredoxins - blue copper proteins
Functional Family Dissimilatory copper-containing nitrite reductase

Enzyme Information
Nitrite reductase (NO-forming).
based on mapping to UniProt Q53239
Nitric oxide + H(2)O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H(+).
-!- The reaction is catalyzed by two types of enzymes, found in the perimplasm of denitrifying bacteria. -!- One type comprises proteins containing multiple copper centers, the other a heme protein, cytochrome cd1. -!- Acceptors include c-type cytochromes such as cytochrome c-550 or cytochrome c-551 from Paracoccus denitrificans or Pseudomonas aeruginosa, and small blue copper proteins such as azurin and pseudoazurin. -!- Cytochrome cd1 also has oxidase and hydroxylamine reductase activities. -!- May also catalyze the reaction of EC since this is a well- known activity of cytochrome cd1. -!- Formerly EC, EC and EC

UniProtKB Entries (1)

Rhodobacter sphaeroides ATCC 17025
Copper-containing nitrite reductase

PDB Structure

External Links
Organism Escherichia
Primary Citation
pH Dependence of Copper Geometry, Reduction Potential, and Nitrite Affinity in Nitrite Reductase
Jacobson, F., Pistorius, A., Farkas, D., De Grip, W., Hansson, O., Sjolin, L., Neutze, R.