CATH Classification

Domain Context

CATH Clusters

Superfamily Cobalt-precorrin-4 Transmethylase; Domain 1
Functional Family

Enzyme Information

2.1.1.98
Diphthine synthase.
based on mapping to UniProt O58456
3 S-adenosyl-L-methionine + 2-((3S)-3-carboxy-3-aminopropyl)-L-histidine- [translation elongation factor 2] = 3 S-adenosyl-L-homocysteine + diphthine-[translation elongation factor 2].
-!- This archaeal enzyme produces the trimethylated product diphthine, which is converted into diphthamide by EC 6.3.1.14. -!- Different from the eukaryotic enzyme, which produces diphthine methyl ester (cf. EC 2.1.1.314). -!- In the archaeon Pyrococcus horikoshii the enzyme acts on His(600) of elongation factor 2.

UniProtKB Entries (1)

O58456
DPHB_PYRHO
Pyrococcus horikoshii OT3
Diphthine synthase

PDB Structure

PDB 2DSG
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of diphthine synthase from Pyrococcus horikoshii OT3
Mizutani, H., Matsuura, Y., Saraboji, K., Malathy Sony, S.M., Ponnuswamy, M.N., Kumarevel, T.S., Kunishima, N.
To be Published