CATH Classification

Domain Context

CATH Clusters

Superfamily 3.30.300.10
Functional Family GMP synthase [glutamine-hydrolyzing]

Enzyme Information

6.3.5.2
GMP synthase (glutamine-hydrolyzing).
based on mapping to UniProt O59072
ATP + XMP + L-glutamine + H(2)O = AMP + diphosphate + GMP + L-glutamate.
-!- Involved in the de novo biosynthesis of guanosine nucleotides. -!- An N-terminal glutaminase domain binds L-glutamine and generates ammonia, which is transferred by a substrate-protective tunnel to the ATP-pyrophosphatase domain. -!- The enzyme can catalyze the second reaction alone in the presence of ammonia. -!- Formerly EC 6.3.4.1.

UniProtKB Entries (1)

O59072
GUAAB_PYRHO
Pyrococcus horikoshii OT3
GMP synthase [glutamine-hydrolyzing] subunit B

PDB Structure

PDB 2DPL
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of the GMP synthase from Pyrococcus horikoshii OT3
Asada, Y., Kunishima, N.
To be Published