CATH Classification

Domain Context

CATH Clusters

Superfamily DD-peptidase/beta-lactamase superfamily
Functional Family 6-aminohexanoate-dimer hydrolase

Enzyme Information

3.5.1.46
6-aminohexanoate-oligomer exohydrolase.
based on mapping to UniProt P07062
(1) (N-(6-aminohexanoyl))(n) + H(2)O = (N-(6-aminohexanoyl))(n-1) + 6-aminohexanoate. (2) N-(6-aminohexanoyl)-6-aminohexanoate + H(2)O = 2 6-aminohexanoate.
-!- The enzyme is involved in degradation of nylon-6 oligomers. -!- It degrades linear oligomers of 6-aminohexanoate with a degree of polymerization of 2-20 by exo-type cleavage, removing residues sequentially from the N-terminus. -!- Activity decreases with the increase of the polymerization number of the oligomer; cf. EC 3.5.1.117 and EC 3.5.2.12.

UniProtKB Entries (1)

P07062
NYLC_FLASK
Flavobacterium sp. K172
6-aminohexanoate-dimer hydrolase

PDB Structure

PDB 2DCF
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Nylon-oligomer degrading enzyme/substrate complex: catalytic mechanism of 6-aminohexanoate-dimer hydrolase
Negoro, S., Ohki, T., Shibata, N., Sasa, K., Hayashi, H., Nakano, H., Yasuhira, K., Kato, D., Takeo, M., Higuchi, Y.
J.Mol.Biol.