CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Cathepsin B

Enzyme Information

3.4.22.1
Cathepsin B.
based on mapping to UniProt P07688
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.
-!- An intracellular (lysosomal) enzyme. -!- Belongs to peptidase family C1.

UniProtKB Entries (1)

P07688
CATB_BOVIN
Bos taurus
Cathepsin B

PDB Structure

PDB 2DC8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Quantitative estimation of each active subsite of cathepsin B for the inhibitory activity, based on the inhibitory activitybinding mode relationship of a series of epoxysuccinyl inhibitors by X-ray crystal structure analyses of the complexes
Watanabe, D., Yamamoto, A., Matsumoto, K., Murata, M., Kitamura, K., Tomoo, K., Ishida, T.
To be Published