CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.4.1.21
Aspartate dehydrogenase.
based on mapping to UniProt O28440
L-aspartate + H(2)O + NAD(P)(+) = oxaloacetate + NH(3) + NAD(P)H.
-!- Catalyzes the first step in NAD biosynthesis from aspartate. -!- Strictly specific for L-aspartate as substrate. -!- Has a higher affinity for NAD(+) than NADP(+).

UniProtKB Entries (1)

O28440
ASPD_ARCFU
Archaeoglobus fulgidus DSM 4304
Probable L-aspartate dehydrogenase

PDB Structure

PDB 2DC1
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of archaeal highly thermostable L-aspartate dehydrogenase/NAD/citrate ternary complex.
Yoneda, K., Sakuraba, H., Tsuge, H., Katunuma, N., Ohshima, T.
Febs J.