CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.50.40
Functional Family

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q14318
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q14318
FKBP8_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase FKBP8

PDB Structure

PDB 2D9F
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution structure of RUH-047, an FKBP domain from human cDNA
Ruhul Momen, A.Z.M., Hirota, H., Koshiba, S., Kigawa, T., Yokoyama, S.
To be Published