CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Sorbitol dehydrogenase

Enzyme Information

1.1.1.103
L-threonine 3-dehydrogenase.
based on mapping to UniProt O58389
L-threonine + NAD(+) = L-2-amino-3-oxobutanoate + NADH.
-!- Acts in concert with EC 2.3.1.29 in the degradation of threonine to glycine. -!- This threonine-degradation pathway is common to prokaryotic and eukaryotic cells and the two enzymes involved form a complex. -!- In aqueous solution, the product L-2-amino-3-oxobutanoate can spontaneously decarboxylate to form aminoacetone.

UniProtKB Entries (1)

O58389
TDH_PYRHO
Pyrococcus horikoshii OT3
L-threonine 3-dehydrogenase

PDB Structure

PDB 2D8A
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of PH0655 from Pyrococcus horikoshii OT3
Asada, Y., Kunishima, N.
To be Published