CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.190.80
Functional Family Inositol-1-monophosphatase

Enzyme Information

3.1.3.25
Inositol-phosphate phosphatase.
based on mapping to UniProt O14732
Myo-inositol phosphate + H(2)O = myo-inositol + phosphate.
-!- Acts on five of the six isomers of myo-inositol phosphate, all except myo-inositol 2-phosphate, but does not act on myo-inositol bearing more than one phosphate group. -!- It also acts on adenosine 2'-phosphate (but not the 3'- or 5'-phosphates), sn-glycerol 3-phosphate and glycerol 2-phosphate, but does not act on inositol bisphosphates or more phosphorylated inositols.

UniProtKB Entries (1)

O14732
IMPA2_HUMAN
Homo sapiens
Inositol monophosphatase 2

PDB Structure

PDB 2CZH
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human myo-inositol monophosphatase 2, the product of the putative susceptibility gene for bipolar disorder, schizophrenia, and febrile seizures
Arai, R., Ito, K., Ohnishi, T., Ohba, H., Akasaka, R., Bessho, Y., Hanawa-Suetsugu, K., Yoshikawa, T., Shirouzu, M., Yokoyama, S.
Proteins