CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.40
Functional Family

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt P46881
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P46881
PAOX_ARTGO
Arthrobacter globiformis
Phenylethylamine oxidase

PDB Structure

PDB 2CWT
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Kinetic and Structural Studies on the Catalytic Role of the Aspartic Acid Residue Conserved in Copper Amine Oxidase(,)
Chiu, Y.C., Okajima, T., Murakawa, T., Uchida, M., Taki, M., Hirota, S., Kim, M., Yamaguchi, H., Kawano, Y., Kamiya, N., Kuroda, S., Hayashi, H., Yamamoto, Y., Tanizawa, K.
Biochemistry