CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.730 | Isoleucyl-tRNA Synthetase; Domain 1 |
|
1.10.730.10 | Isoleucyl-tRNA Synthetase; Domain 1 |
Domain Context
CATH Clusters
| Superfamily | Isoleucyl-tRNA Synthetase; Domain 1 |
| Functional Family | Methionine-tRNA ligase |
Enzyme Information
| 6.1.1.10 |
Methionine--tRNA ligase.
based on mapping to UniProt O67298
ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl- tRNA(Met).
-!- In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.
|
UniProtKB Entries (1)
| O67298 |
SYM_AQUAE
Aquifex aeolicus VF5
Methionine--tRNA ligase
|
PDB Structure
| PDB | 2CSX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Structural basis for anticodon recognition by methionyl-tRNA synthetase.
Nat.Struct.Mol.Biol.
|
