CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.10 | Ribbon |
|
2.10.110 | Cysteine Rich Protein |
|
2.10.110.10 | Cysteine Rich Protein |
Domain Context
CATH Clusters
| Superfamily | Cysteine Rich Protein |
| Functional Family | F-actin-monooxygenase MICAL1 isoform 1 |
Enzyme Information
| 1.14.13.225 |
F-actin monooxygenase.
based on mapping to UniProt Q8TDZ2
[F-actin]-L-methionine + NADPH + O(2) + H(+) = [F-actin]-L-methionine- (R)-S-oxide + NADP(+) + H(2)O.
-!- The enzyme, characterized from the fruit fly Drosophila melanogaster, is a multi-domain oxidoreductase that acts as an F-actin disassembly factor. -!- The enzyme selectively reduces two L-Met residues of F-actin, causing fragmentation of the filaments and preventing repolymerization. -!- Free methionine is not a substrate. -!- The reaction is stereospecific and generates the (R)-sulfoxide.
|
UniProtKB Entries (1)
| Q8TDZ2 |
MICA1_HUMAN
Homo sapiens
[F-actin]-monooxygenase MICAL1
|
PDB Structure
| PDB | 2CO8 |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution structures of the LIM domain of human NEDD9 interacting protein with calponin homology and LIM domains
To be Published
|