CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.5 | Ribosomal Protein L9; domain 1 |
|
3.40.5.120 |
Domain Context
CATH Clusters
| Superfamily | 3.40.5.120 |
| Functional Family | Chromodomain-helicase-DNA-binding protein 8 |
Enzyme Information
| 3.6.4.12 |
DNA helicase.
based on mapping to UniProt Q9HCK8
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).
|
UniProtKB Entries (1)
| Q9HCK8 |
CHD8_HUMAN
Homo sapiens
Chromodomain-helicase-DNA-binding protein 8
|
PDB Structure
| PDB | 2CKA |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
Solution Structures of the Brk Domains of the Human Chromo Helicase Domain 7 and 8, Reveals Structural Similarity with Gyf Domain Suggesting a Role in Protein Interaction
To be Published
|