CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Short-chain dehydrogenase reductase |
Enzyme Information
| 1.1.1.268 |
2-(R)-hydroxypropyl-CoM dehydrogenase.
based on mapping to UniProt Q56840
2-(R)-hydroxypropyl-CoM + NAD(+) = 2-oxopropyl-CoM + NADH.
-!- Highly specific for (R)-2-hydroxyalkyl thioethers of CoM, in contrast to EC 1.1.1.269, which is highly specific for the (S)-enantiomer. -!- Forms component III of a four-component enzyme system (comprising EC 4.4.1.23 (component I), EC 1.8.1.5 (component II), EC 1.1.1.268 (component III) and EC 1.1.1.269 (component IV)) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2.
|
UniProtKB Entries (1)
| Q56840 |
HCDR_XANP2
Xanthobacter autotrophicus Py2
2-(R)-hydroxypropyl-CoM dehydrogenase
|
PDB Structure
| PDB | 2CFC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Basis for Stereoselectivity in the (R)-and (S)-Hydroxypropylthioethanesulfonate Dehydrogenases.
Biochemistry
|