CATH Classification

Domain Context

CATH Clusters

Superfamily Medium-chain alcohol dehydrogenases, catalytic domain
Functional Family Glucose 1-dehydrogenase

Enzyme Information

1.1.1.120
Galactose 1-dehydrogenase (NADP(+)).
based on mapping to UniProt O93715
D-galactose + NADP(+) = D-galactono-1,5-lactone + NADPH.
-!- Also acts on L-arabinose, 6-deoxy- and 2-deoxy-D-galactose.
1.1.1.48
D-galactose 1-dehydrogenase.
based on mapping to UniProt O93715
D-galactose + NAD(+) = D-galactono-1,4-lactone + NADH.
-!- This enzyme is part of the De Ley-Doudoroff pathway, which is used by some bacteria during growth on D-galactose.
1.1.1.359
Aldose 1-dehydrogenase (NAD(P)(+)).
based on mapping to UniProt O93715
An aldopyranose + NAD(P)(+) = an aldono-1,5-lactone + NAD(P)H.
-!- The enzyme from the archaeon Sulfolobus solfataricus shows broad specificity toward aldoses (D-glucose, D-galactose, D-xylose, L-arabinose, 6-deoxy-D-glucose, D-fucose) and can utilize NAD(+) and NADP(+) with similar catalytic efficiency. -!- It is involved in aldose catabolism via the branched variant of the Entner-Doudoroff pathway.
1.1.1.47
Glucose 1-dehydrogenase (NAD(P)(+)).
based on mapping to UniProt O93715
D-glucose + NAD(P)(+) = D-glucono-1,5-lactone + NAD(P)H.
-!- This enzyme has similar activity with either NAD(+) or NADP(+). -!- Cf. EC 1.1.1.118 and EC 1.1.1.119.

UniProtKB Entries (1)

O93715
GLCDH_SACSO
Saccharolobus solfataricus
Glucose 1-dehydrogenase

PDB Structure

PDB 2CDC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus.
Milburn, C.C., Lamble, H.J., Theodossis, A., Bull, S.D., Hough, D.W., Danson, M.J., Taylor, G.L.
J. Biol. Chem.