CATH Classification

Domain Context

CATH Clusters

Superfamily Peroxidase, domain 2
Functional Family

Enzyme Information

1.11.1.21
Catalase peroxidase.
based on mapping to UniProt P9WIE5
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

UniProtKB Entries (1)

P9WIE5
KATG_MYCTU
Mycobacterium tuberculosis H37Rv
Catalase-peroxidase

PDB Structure

PDB 2CCA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Hydrogen Peroxide-Mediated Isoniazid Activation Catalyzed by Mycobacterium Tuberculosis Catalase-Peroxidase (Katg) and its S315T Mutant.
Zhao, X., Yu, H., Yu, S., Wang, F., Sacchettini, J.C., Magliozzo, R.S.
Biochemistry