CATH Classification

Domain Context

CATH Clusters

Superfamily RuvB-like helicase, domain II
Functional Family RuvB-like helicase

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q9Y265
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q9Y265
RUVB1_HUMAN
Homo sapiens
RuvB-like 1

PDB Structure

PDB 2C9O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of the human AAA+ protein RuvBL1.
Matias, P.M., Gorynia, S., Donner, P., Carrondo, M.A.
J. Biol. Chem.