CATH Classification

Domain Context

CATH Clusters

Superfamily 2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92
Endopeptidase Clp.
based on mapping to UniProt P9WPC5
Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).
-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

P9WPC5
CLPP1_MYCTU
Mycobacterium tuberculosis H37Rv
ATP-dependent Clp protease proteolytic subunit 1

PDB Structure

PDB 2C8T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insights Into the Inter-Ring Plasticity of Caseinolytic Proteases from the X-Ray Structure of Mycobacterium Tuberculosis Clpp1.
Ingvarsson, H., Mate, M.J., Hogbom, M., Portnoi, D., Benaroudj, N., Alzari, P.M., Ortiz-Lombardia, M., Unge, T.
Acta Crystallogr.,Sect.D