CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Enzyme Information

1.1.1.267
1-deoxy-D-xylulose-5-phosphate reductoisomerase.
based on mapping to UniProt P9WNS1
2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.
-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

P9WNS1
DXR_MYCTU
Mycobacterium tuberculosis H37Rv
1-deoxy-D-xylulose 5-phosphate reductoisomerase

PDB Structure

PDB 2C82
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The 1.9 A Resolution Structure of Mycobacterium Tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase, a Potential Drug Target.
Henriksson, L.M., Bjorkelid, C., Mowbray, S.L., Unge, T.
Acta Crystallogr.,Sect.D