CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Glutathione S-transferase theta-1

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt P30711
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

P30711
GSTT1_HUMAN
Homo sapiens
Glutathione S-transferase theta-1

PDB Structure

PDB 2C3Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis of the Suppressed Catalytic Activity of Wild-Type Human Glutathione Transferase T1-1 Compared to its W234R Mutant.
Tars, K., Larsson, A.-K., Shokeer, A., Olin, B., Mannervik, B., Kleywegt, G.J.
J.Mol.Biol.