CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P00374
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P00374
DYR_HUMAN
Homo sapiens
Dihydrofolate reductase

PDB Structure

PDB 2C2S
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural Evaluation.
Reynolds, R.C., Campbell, S.R., Fairchild, R.G., Kisliuk, R.L., Micca, P.L., Queener, S.F., Riordan, J.M., Sedwick, W.D., Waud, W.R., Leung, A.K.W., Dixon, R.W., Suling, W.J., Borhani, D.W.
J.Med.Chem.