CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.630.30
Functional Family Mycothiol acetyltransferase

Enzyme Information

2.3.1.189
Mycothiol synthase.
based on mapping to UniProt P9WJM7
Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.
-!- This enzyme catalyzes the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium. -!- The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs). -!- The enzyme has been purified from Mycobacterium tuberculosis H37Rv. -!- Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate.

UniProtKB Entries (1)

P9WJM7
MSHD_MYCTU
Mycobacterium tuberculosis H37Rv
Mycothiol acetyltransferase

PDB Structure

PDB 2C27
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Substrate-Induced Conformational Change of Mycobacterium Tuberculosis Mycothiol Synthase.
Vetting, M.W., Yu, M., Rendle, P.M., Blanchard, J.S.
J.Biol.Chem.