CATH Classification

Domain Context

CATH Clusters

Superfamily 3.90.640.30
Functional Family

Enzyme Information

3.5.1.104
Peptidoglycan-N-acetylglucosamine deacetylase.
based on mapping to UniProt Q8DP63
Peptidoglycan-N-acetyl-D-glucosamine + H(2)O = peptidoglycan-D- glucosamine + acetate.
-!- Modification of peptidoglycan by N-deacetylation is an important factor in virulence of Helicobacter pylori, Listeria monocytogenes and Streptococcus suis. -!- The enzyme from Streptococcus pneumoniae is a metalloenzyme using a His-His-Asp zinc-binding triad with a nearby aspartic acid and histidine acting as the catalytic base and acid, respectively.

UniProtKB Entries (1)

Q8DP63
PGDA_STRR6
Streptococcus pneumoniae R6
Peptidoglycan-N-acetylglucosamine deacetylase

PDB Structure

PDB 2C1I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor.
Blair, D.E., Schuttelkopf, A.W., MacRae, J.I., van Aalten, D.M.
Proc. Natl. Acad. Sci. U.S.A.