CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1050 | Nonspecific Lipid-transfer Protein; Chain A |
|
3.30.1050.10 | SCP2 sterol-binding domain |
Domain Context
CATH Clusters
| Superfamily | SCP2 sterol-binding domain |
| Functional Family |
Enzyme Information
| 2.3.1.176 |
Propanoyl-CoA C-acyltransferase.
based on mapping to UniProt P22307
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl- CoA.
-!- Also acts on dihydroxy-5-beta-cholestanoyl-CoA and other branched chain acyl-CoA derivatives. -!- Catalyzes the penultimate step in the formation of bile acids. -!- The bile acid moiety is transferred from the acyl-CoA thioester (RCO- SCoA) to either glycine or taurine (NH(2)R') by EC 2.3.1.65. -!- Formerly EC 2.3.1.154.
|
UniProtKB Entries (1)
| P50542 |
PEX5_HUMAN
Homo sapiens
Peroxisomal targeting signal 1 receptor
|
PDB Structure
| PDB | 2C0L |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Recognition of a Functional Peroxisome Type 1 Target by the Dynamic Import Receptor Pex5P.
Mol.Cell
|