CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P08631
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P08631
HCK_HUMAN
Homo sapiens
Tyrosine-protein kinase HCK

PDB Structure

PDB 2C0I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection.
Burchat, A., Borhani, D.W., Calderwood, D.J., Hirst, G.C., Li, B., Stachlewitz, R.F.
Bioorg.Med.Chem.Lett.