CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.360
Functional Family

Enzyme Information

1.10.5.1
Ribosyldihydronicotinamide dehydrogenase (quinone).
based on mapping to UniProt P16083
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D- ribofuranosyl)nicotinamide + a quinol.
-!- Unlike EC 1.6.5.2, this quinone reductase cannot use NADH or NADPH; instead it uses N-ribosyl- and N-alkyldihydronicotinamides. -!- Polycyclic aromatic hydrocarbons, such as benz[a]anthracene, and the estrogens 17-beta-estradiol and diethylstilbestrol are potent inhibitors, but dicoumarol is only a very weak inhibitor. -!- This enzyme can catalyze both 2-electron and 4-electron reductions, but one-electron acceptors, such as potassium ferricyanide, cannot be reduced. -!- Formerly EC 1.10.99.2.

UniProtKB Entries (1)

P16083
NQO2_HUMAN
Homo sapiens
Ribosyldihydronicotinamide dehydrogenase [quinone]

PDB Structure

PDB 2BZS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Binding of the Anticancer Prodrug Cb1954 to the Activating Enzyme Nqo2 Revealed by the Crystal Structure of Their Complex.
Abu Khader, M.M., Heap, J.T., De Matteis, C., Kellam, B., Doughty, S.W., Minton, N., Paoli, M.
J.Med.Chem.