CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Prothrombin

Enzyme Information

3.4.21.5
Thrombin.
based on mapping to UniProt P00734
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.

UniProtKB Entries (2)

P00734
THRB_HUMAN
Homo sapiens
Prothrombin
P09945
HIRV2_HIRME
Hirudo medicinalis
Hirudin variant-2

PDB Structure

PDB 2BXT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and Discovery of Novel, Potent Pyrazinone-Based Thrombin Inhibitors with a Solubilizing P1-P2-Linker
Bulat, S., Bosio, S., Papadopoulos, M.A., Cerezo-Galvez, S., Grabowski, E., Rosenbaum, C., Matassa, V.G., Ott, I., Metz, G., Schamberger, J., Sekul, R., Feurer, A.
Lett.Drug Des.Discovery