CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.20.820
Functional Family

Enzyme Information

1.3.5.4
Fumarate reductase (quinol).
based on mapping to UniProt P17412
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme, which is found in anaerobic and facultative organisms such as bacteria, parasitic helminthes, and lower marine organisms, utilizes low potential quinols, such as menaquinol and rhodoquinol, to reduce fumarate as the final step of an anaerobic respiratory chain. -!- The enzyme is known as complex II of the electron transfer chain, similarly to EC 1.3.5.1, to which it is closely related.

UniProtKB Entries (1)

P17412
FRDA_WOLSU
Wolinella succinogenes DSM 1740
Fumarate reductase flavoprotein subunit

PDB Structure

PDB 2BS3
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Experimental Support for the E-Pathway Hypothesis of Coupled Transmembrane Electron and Proton Transfer in Dihemic Quinol:Fumarate Reductase
Lancaster, C.R.D., Sauer, U.S., Gross, R., Haas, A.H., Graf, J., Schwalbe, H., Maentele, W., Simon, J., Madej, G.
Proc.Natl.Acad.Sci.USA