CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.220 | Chondroitinase Ac; Chain A, domain 3 |
|
2.60.220.10 | Polysaccharide lyase family 8-like, C-terminal |
Domain Context
CATH Clusters
| Superfamily | Polysaccharide lyase family 8-like, C-terminal |
| Functional Family |
Enzyme Information
| 4.2.2.1 |
Hyaluronate lyase.
based on mapping to UniProt Q54873
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4- enuronosyl)-N-acetyl-D-glucosamine.
-!- The enzyme catalyzes the degradation of hyaluronan by a beta- elimination reaction. -!- Also acts on chondroitin. -!- The product is more systematically known as 3-(4-deoxy-alpha-L-threo- hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose. -!- Formerly EC 4.2.99.1.
|
UniProtKB Entries (1)
| Q54873 |
HYSA_STRPN
Streptococcus pneumoniae TIGR4
Hyaluronate lyase
|
PDB Structure
| PDB | 2BRP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Design of new benzoxazole-2-thione-derived inhibitors of Streptococcus pneumoniae hyaluronan lyase: structure of a complex with a 2-phenylindole.
Glycobiology
|